Anti-F19A5 FAM19A5 Antibody

Expressed in the subcutaneous and perirenal adipose tissue (at protein level) (PubMed:29453251) . Highly expressed in adipose tissue with moderate expression in the brain and ovary (PubMed:29453251) . Isoform 2: Brain-specific (PubMed:15028294) .

Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein- coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity) . Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity) . Blocks TNFSF11/RANKL- induced osteoclast formation from macrophages by inhibiting up- regulation of osteoclast fusogenic and differentiation genes (By similarity) . Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity) . Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity) . Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity) .