Anti-LITAF Antibody

Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352) . Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades (PubMed:23166352) . Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352) . Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429) . May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005) . Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005) . May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005) .