Anti-Dickkopf-related protein 2 DKK2 Antibody

Boster Bio Anti-Dickkopf-related protein 2 DKK2 Antibody catalog # A06431. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Dickkopf-related protein 2; Dickkopf-2; Dkk-2; hDkk-2; DKK2; UNQ682/PRO1316;

Gene Name

DKK2

UniProt

Q9UBU2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, brain, skeletal muscle and lung.

Applications

WB, ELISA

Purification

DKK2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Form

Liquid

Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) . .