Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-CILP1 Antibody

Boster Bio Anti-CILP1 Antibody catalog # A06239. Tested in ELISA, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Cartilage intermediate layer protein 1; CILP-1; Cartilage intermediate-layer protein; Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2; CILP; UNQ602/PRO1188;

Gene Name

CILP

UniProt

O75339

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Tissue Specificity

Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD) . Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses.

Applications

WB, ELISA

Purification

CILP1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Form

Liquid

Function

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

Molecular Weight

132565 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A06239

Product MSDS

https://www.bosterbio.com/msds?sku=A06239

Fragment

IgG

Other Gene Names

Cartilage intermediate layer protein 1

Subcellular Location

Secreted, extracellular space, extracellular matrix

Protein Name

Cartilage intermediate layer protein 1

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Rabbit Sideroflexin 1 ELISA Kit
MBS080913 Inquire

Rabbit Sideroflexin 1 ELISA Kit

Ask
View Details
Rabbit anti-Escherichia coli (strain K12) mppA Polyclonal Antibody
MBS7149129 Inquire

Rabbit anti-Escherichia coli (strain K12) mppA Polyclonal Antibody

Ask
View Details
Rabbit anti-Shigella flexneri RSGA Polyclonal Antibody
MBS7199597 Inquire

Rabbit anti-Shigella flexneri RSGA Polyclonal Antibody

Ask
View Details
Recombinant Bacillus subtilis Uncharacterized protein yddT (yddT)
MBS1087082-01 0.02 mg (E-Coli)

Recombinant Bacillus subtilis Uncharacterized protein yddT (yddT)

Ask
View Details
Recombinant Bacillus subtilis Uncharacterized protein yddT (yddT)
MBS1087082-02 0.1 mg (E-Coli)

Recombinant Bacillus subtilis Uncharacterized protein yddT (yddT)

Ask
View Details
Recombinant Bacillus subtilis Uncharacterized protein yddT (yddT)
MBS1087082-03 0.02 mg (Yeast)

Recombinant Bacillus subtilis Uncharacterized protein yddT (yddT)

Ask
View Details