Anti-CILP1 Antibody

Boster Bio Anti-CILP1 Antibody catalog # A06239. Tested in ELISA, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Cartilage intermediate layer protein 1; CILP-1; Cartilage intermediate-layer protein; Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2; CILP; UNQ602/PRO1188;

Gene Name

CILP

UniProt

O75339

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Tissue Specificity

Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD) . Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses.

Applications

WB, ELISA

Purification

CILP1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Form

Liquid

Function

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.