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Anti-SIGIR SIGIRR Antibody

Boster Bio Anti-SIGIR SIGIRR Antibody catalog # A03373-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8; TIR8; SIGIRR; UNQ301/PRO342;

Gene Name

SIGIRR

UniProt

Q6IA17

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in epithelial tissues such as kidney, lung and gut.

Applications

WB, ELISA

Purification

SIGIR antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Form

Liquid

Function

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Molecular Weight

45679 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Single Ig IL-1-related receptor

Subcellular Location

Membrane ; Single-pass type III membrane protein .

Protein Name

Single Ig IL-1-related receptor

Frequently Asked Questions

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