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Anti-DEDD Antibody

Boster Bio Anti-DEDD Antibody catalog # A06463. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Death effector domain-containing protein; DEDPro1; Death effector domain-containing testicular molecule; FLDED-1; DEDD; DEDPRO1, DEFT; KE05;

Gene Name

DEDD

UniProt

O75618

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human protein at AA range: 90-170

Clonality

Polyclonal

Tissue Specificity

Widely expressed with highest levels in testis.

Applications

WB, ELISA

Purification

DEDD antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Form

Liquid

Function

A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity) .

Molecular Weight

36794 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Death effector domain-containing protein

Subcellular Location

Cytoplasm. Nucleus, nucleolus . Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity) . Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. .

Protein Name

Death effector domain-containing protein

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