Anti-UBP6 USP6 Antibody
Boster Bio Anti-UBP6 USP6 Antibody catalog # A05340. Tested in ELISA, WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Ubiquitin carboxyl-terminal hydrolase 6;3.4.19.12; Deubiquitinating enzyme 6; Proto-oncogene TRE-2; Ubiquitin thioesterase 6; Ubiquitin-specific-processing protease 6; USP6; HRP1, TRE2;
Gene Name
USP6
UniProt
P35125
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Tissue Specificity
Testis specific. Expressed in various cancer cell lines.
Applications
WB, ELISA
Purification
UBP6 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Form
Liquid
Function
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Molecular Weight
158658 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Ubiquitin carboxyl-terminal hydrolase 6
Subcellular Location
Cell membrane. Cytoplasm. Endosome. Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.
Protein Name
Ubiquitin carboxyl-terminal hydrolase 6
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