Anti-NAC3 SLC8A3 Antibody

Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.

Mediates the electrogenic exchange of Ca (2+) against Na (+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca (2+) levels and Ca (2+) -dependent cellular processes. Contributes to cellular Ca (2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca (2+) levels due to release of Ca (2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca (2+) from the cell during the next phase, so that cytoplasmic Ca (2+) levels rapidly return to baseline. Contributes to Ca (2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca (2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity) . Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935) . Mediates Ca (2+) efflux from mitochondria and contributes to mitochondrial Ca (2+) ion homeostasis (By similarity) .