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Anti-ARHG4 ARHGEF4 Antibody

Boster Bio Anti-ARHG4 ARHGEF4 Antibody catalog # A07246. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Rho guanine nucleotide exchange factor 4; APC-stimulated guanine nucleotide exchange factor 1; Asef; Asef1; ARHGEF4; KIAA1112;

Gene Name

ARHGEF4

UniProt

Q9NR80

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from human protein at AA range: 270-350

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors.

Applications

WB, ELISA

Purification

ARHG4 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Form

Liquid

Function

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Molecular Weight

79067 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Rho guanine nucleotide exchange factor 4

Subcellular Location

Isoform 3: Cytoplasm. Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Associated with membrane ruffles. .

Protein Name

Rho guanine nucleotide exchange factor 4

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