Anti-Polycystin-1 PKD1 Antibody

Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281) . Both PKD1 and PKD2 are required for channel activity (PubMed:27214281) . Involved in renal tubulogenesis (PubMed:12482949) . Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity) . Acts as a regulator of cilium length, together with PKD2 (By similarity) . The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity) . The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity) . May be an ion- channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.