Anti-Polycystin-1 PKD1 Antibody
Boster Bio Anti-Polycystin-1 PKD1 Antibody catalog # A00628. Tested in IHC applications. This antibody reacts with Human.
Product Specifications
Synonyms
Polycystin-1 ; PC1; Autosomal dominant polycystic kidney disease 1 protein; PKD1
Gene Name
PKD1
UniProt
P98161
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from human PKD1 protein.
Clonality
Polyclonal
Applications
IHC
Purification
PKD1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
IHC-p 1:50-300
Form
Liquid
Function
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281) . Both PKD1 and PKD2 are required for channel activity (PubMed:27214281) . Involved in renal tubulogenesis (PubMed:12482949) . Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity) . Acts as a regulator of cilium length, together with PKD2 (By similarity) . The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity) . The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity) . May be an ion- channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
Molecular Weight
462529 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Polycystin-1
Subcellular Location
Cell membrane
Protein Name
Polycystin-1
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