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Anti-Netrin receptor UNC5B UNC5B Antibody

Boster Bio Anti-Netrin receptor UNC5B UNC5B Antibody catalog # A03986. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Netrin receptor UNC5B; Protein unc-5 homolog 2; Protein unc-5 homolog B; p53-regulated receptor for death and life protein 1

Gene Name

UNC5B

UniProt

Q8IZJ1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human protein at AA range: 350-430

Clonality

Polyclonal

Tissue Specificity

Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.

Applications

WB, ELISA

Purification

UNC5B antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Form

Liquid

Function

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity) . Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity) . It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906) . Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity) .

Molecular Weight

103638 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A03986

Product MSDS

https://www.bosterbio.com/msds?sku=A03986

Fragment

IgG

Other Gene Names

Netrin receptor UNC5B

Subcellular Location

Cell membrane

Protein Name

Netrin receptor UNC5B

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