Anti-MPP8 MPHOSPH8 Antibody
Boster Bio Anti-MPP8 MPHOSPH8 Antibody catalog # A11685. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
M-phase phosphoprotein 8; Two hybrid-associated protein 3 with RanBPM
Gene Name
MPHOSPH8
UniProt
Q99549
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human protein at AA range: 290-370
Clonality
Polyclonal
Applications
ELISA, WB
Purification
MPP8 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Form
Liquid
Function
Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416) . Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416) . Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592) . Mediates down-regulation of CDH1 expression (PubMed:20871592) .
Molecular Weight
97182 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
M-phase phosphoprotein 8
Subcellular Location
Nucleus
Protein Name
M-phase phosphoprotein 8
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