Anti-GNA12 Antibody

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452) . Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387) . GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity) . GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996) . Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452) . Inhibits CDH1- mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920) . Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433) . May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986) .