Anti-HECW1 Antibody
Boster Bio Anti-HECW1 Antibody catalog # A11214. Tested in ELISA, WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
E3 ubiquitin-protein ligase HECW1;2.3.2.26; HECT, C2 and WW domain-containing protein 1; HECT-type E3 ubiquitin transferase HECW1; NEDD4-like E3 ubiquitin-protein ligase 1; hNEDL1; HECW1; KIAA0322, NEDL1;
Gene Name
HECW1
UniProt
Q76N89
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Tissue Specificity
Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
Applications
WB, ELISA
Purification
HECW1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Form
Liquid
Function
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS) . Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
Molecular Weight
179554 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
E3 ubiquitin-protein ligase HECW1
Subcellular Location
Cytoplasm
Protein Name
E3 ubiquitin-protein ligase HECW1
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