Anti-HACE1 Antibody
Boster Bio Anti-HACE1 Antibody catalog # A04757-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
E3 ubiquitin-protein ligase HACE1;2.3.2.26; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1; HACE1; KIAA1320;
Gene Name
HACE1
UniProt
Q8IYU2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Tissue Specificity
Expressed in multiple tissues including heart, brain and kidney.
Applications
WB, ELISA
Purification
HACE1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Form
Liquid
Function
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
Molecular Weight
102342 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
E3 ubiquitin-protein ligase HACE1
Subcellular Location
Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
Protein Name
E3 ubiquitin-protein ligase HACE1
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