Glycyrin

Glycyrin is a PPAR-γ ligand of licorice. Glycyrin can decrease the blood glucose levels of genetically diabetic mice. Glycyrin also shows antibacterial activity[1][2][3].

Product Specifications

CAS Number

[66056-18-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; PPAR

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glycyrin.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C1C(C2=CC=C(O)C=C2O)=CC3=C(OC)C(C/C=C(C)\C)=C(OC)C=C3O1

Molecular Formula

C22H22O6

Molecular Weight

382.41

Precautions

H302, H315, H319, H335

References & Citations

[2]Tanaka Y, et, al. Antibacterial compounds of licorice against upper airway respiratory tract pathogens. J Nutr Sci Vitaminol (Tokyo) . 2001 Jun;47 (3) :270-3.|[3]Wang Q, et, al. Metabolites identification of glycyrin and glycyrol, bioactive coumarins from licorice. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 1:983-984:39-46.|[1]Kuroda M, et, al. Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A (y) mice. Bioorg Med Chem Lett. 2003 Dec 15;13 (24) :4267-72.