Anti-Claspin CLSPN Antibody
Boster Bio Anti-Claspin CLSPN Antibody catalog # A03249. Tested in ELISA, WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Claspin; hClaspin; CLSPN;
Gene Name
CLSPN
UniProt
Q9HAW4
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from human protein at AA range: 10-90
Clonality
Polyclonal
Applications
WB, ELISA
Purification
CLSPN antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Form
Liquid
Function
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC) . This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Molecular Weight
151094 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Claspin
Subcellular Location
Nucleus
Protein Name
Claspin
Frequently Asked Questions
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