Anti-Hu CD243 Purified ABCB1 Monoclonal Antibody

Boster Bio Anti-Hu CD243 Purified ABCB1 Monoclonal Antibody (Catalog# M00049-2) . Tested in Flow Cytometry, IP, IHC-P, IHC-F application (s) . This antibody reacts with Human.

Product Specifications

Background

CD243, also known as multidrug resistant protein 1 (MDR-1) or P-glycoprotein (Pgp) is an ATP binding cassette (ABC) -containing efflux transporter for xenobiotic lipophilic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in many tissues, including the brain, liver, pancreas, testes, kidney, and blood (B, T, NK cells, but not monocytes) .

Synonyms

P-Glycoprotein, CLCS, MDR1, PGY1, ABC20, GP170, ABCB1, ABC transporter

Gene Name

ABCB1

UniProt

P08183

Host

Mouse

Reactivity

Human

Immunogen

NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA. The mouse monoclonal antibody UIC2 recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, T, and NK cells, or on many multidrug resistant cancer cells. This antibody preferentially recognizes CD243 in the process of transporting substrate.