Anti-Hu CD1b Purified Monoclonal Antibody

Boster Bio Anti-Hu CD1b Purified Monoclonal Antibody (Catalog# M02158-1) . Tested in Flow Cytometry, IP, IHC-P, IHC-F application (s) . This antibody reacts with Human.

Product Specifications

Background

CD1b (also known as R1) together with CD1a and c, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. Besides non-peptide glycolipid antigen presentation to CD1-restricted T cells, CD1b has been implicated in thymocyte development.

Synonyms

T-cell surface glycoprotein CD1b; CD1b; CD1B;

Gene Name

CD1B

UniProt

P29016

Host

Mouse

Reactivity

Human

Immunogen

A cell membrane antigen preparation that was isolated from normal human thymocytes. The mouse monoclonal antibody SN13 (also known as K5-1B8) recognizes an extracellular epitope of CD1b, a 44 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells.

Clonality

Monoclonal

Clone

Clone: SN13

Tissue Specificity

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Applications

Flow Cytometry, IP, IHC-P, IHC-F

Purification

Purified by protein-A affinity chromatography.

Concentration

1 mg/ml

Dilution

Flow cytometry: 1-4 μg/ml.

Form

Liquid

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.