Anti-Hu CD266 Purified TNFRSF12A Monoclonal Antibody

Boster Bio Anti-Hu CD266 Purified TNFRSF12A Monoclonal Antibody (Catalog# M06261-1) . Tested in Flow Cytometry, WB, IHC-F application (s) . This antibody reacts with Mouse, Human.

Product Specifications

Background

CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.

Synonyms

TWEAKR, FN14, TNFRSF12A

Gene Name

TNFRSF12A

UniProt

Q9NP84

Host

Mouse

Reactivity

Mouse, Human

Immunogen

Human CD266-transfected P815 cells. The mouse monoclonal antibody ITEM-4 recognizes an extracellular epitope of CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.

Clonality

Monoclonal

Clone

Clone: ITEM-4

Tissue Specificity

Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

Applications

Flow Cytometry, WB, IHC-F

Purification

Purified by protein-A affinity chromatography.

Concentration

1 mg/ml

Dilution

Flow cytometry: 1-4 µg/ml

Form

Liquid

Function

Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.