Anti-AGR3 Purified Monoclonal Antibody
Boster Bio Anti-AGR3 Purified Monoclonal Antibody (Catalog# M05950) . Tested in WB, IHC-P, IHC-F, ICC application (s) . This antibody reacts with Human.
Product Specifications
Background
AGR3 (Anterior Gradient 3) protein, also known as AG3 (hAG-3, HAG3 in human), or BCMP11, is a secreted cytoplasmic protein which is involved in metastasis induction and p53 tumour supressor inhibition. It may serve as molecular marker and potential therapeutic target for hormone-responsive breast tumours. Its Xenopus homolog is associated with anteroposterior fate determination during early development.
Synonyms
AG3, HAG3
Gene Name
AGR3
UniProt
Q8TD06
Host
Mouse
Reactivity
Human
Immunogen
Purified human AGR3 protein. The antibody AGR3.1 recognizes the epitope HETTDKNLS within the AGR3 (AG3) protein (19-20 kDa) ; a secreted cytoplasmic protein which can serve as a marker of carcinogenesis.
Clonality
Monoclonal
Clone
Clone: AGR3.1
Tissue Specificity
Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668) . Expression increased with differentiation of airway epithelial cells (PubMed:25751668) . Not detected in the mucous cells (PubMed:25751668) . Expressed in ciliated cells in the oviduct (PubMed:26170690) . Also detected in stomach, colon, prostate and liver (PubMed:25751668) . Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690) . Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690) .
Applications
WB, IHC-P, IHC-F, ICC
Purification
Purified by protein-A affinity chromatography.
Concentration
1 mg/ml
Form
Liquid
Function
Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.
Molecular Weight
19171 MW
Shipping Conditions
Available
Storage Conditions
Store at 2-8°C. Do not freeze.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=M05950
Product MSDS
https://www.bosterbio.com/msds?sku=M05950
Fragment
Mouse IgG1
Other Gene Names
Anterior gradient 3, protein disulphide isomerase
Subcellular Location
Endoplasmic reticulum
Protein Name
Anterior gradient protein 3
Curated Selection
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