Anti-AGR3 Purified Monoclonal Antibody

AGR3 (Anterior Gradient 3) protein, also known as AG3 (hAG-3, HAG3 in human), or BCMP11, is a secreted cytoplasmic protein which is involved in metastasis induction and p53 tumour supressor inhibition. It may serve as molecular marker and potential therapeutic target for hormone-responsive breast tumours. Its Xenopus homolog is associated with anteroposterior fate determination during early development.

Purified human AGR3 protein. The antibody AGR3.1 recognizes the epitope HETTDKNLS within the AGR3 (AG3) protein (19-20 kDa) ; a secreted cytoplasmic protein which can serve as a marker of carcinogenesis.

Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668) . Expression increased with differentiation of airway epithelial cells (PubMed:25751668) . Not detected in the mucous cells (PubMed:25751668) . Expressed in ciliated cells in the oviduct (PubMed:26170690) . Also detected in stomach, colon, prostate and liver (PubMed:25751668) . Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690) . Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690) .

Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.