Anti-ARAP1 Purified Monoclonal Antibody
Boster Bio Anti-ARAP1 Purified Monoclonal Antibody (Catalog# M06167) . Tested in IP, WB, ICC application (s) . This antibody reacts with Human.
Product Specifications
Background
ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.
Synonyms
CED2, CENTD2
Gene Name
ARAP1
UniProt
Q96P48
Host
Mouse
Reactivity
Human
Immunogen
His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1. The antibody ARAP1-2 reacts with C-terminal part of ARAP1 (intracellular epitope), a 160 kDa adaptor protein.
Clonality
Monoclonal
Clone
Clone: ARAP1-2
Tissue Specificity
Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.
Applications
IP, WB, ICC
Purification
Purified by protein-A affinity chromatography.
Concentration
1 mg/ml
Dilution
Western blotting: 2 μg/ml
Form
Liquid
Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns (3,4,5) P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns (3,4,5) P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity) .
Molecular Weight
162192 MW
Shipping Conditions
Available
Storage Conditions
Store at 2-8°C. Do not freeze.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=M06167
Product MSDS
https://www.bosterbio.com/msds?sku=M06167
Fragment
Mouse IgG1
Other Gene Names
ArfGAP with RhoGAP domain, ankyrin repeat and PH d
Subcellular Location
Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.
Protein Name
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
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