Anti-Hu CD42b Purified GP1BA Monoclonal Antibody
Boster Bio Anti-Hu CD42b Purified GP1BA Monoclonal Antibody (Catalog# M02073-1) . Tested in Flow Cytometry, IHC-F application (s) . This antibody reacts with Primate, Human.
Product Specifications
Background
CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Synonyms
BSS, GP1B, VWDP, CD42B, GPIbA, BDPLT1, BDPLT3, DBPLT3
Gene Name
GP1BA
UniProt
P07359
Host
Mouse
Reactivity
Primate, Human
Immunogen
Peripheral blood mononuclear cells of a patient suffering with CLL. The antibody HIP1 reacts with an extracellular epitope of CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa) ; CD42b/c forms a noncovalent complex with CD42a and CD42d.
Clonality
Monoclonal
Clone
Clone: HIP1
Applications
Flow Cytometry, IHC-F
Purification
Purified by protein-A affinity chromatography.
Concentration
1 mg/ml
Dilution
Flow cytometry: 1-4 µg/ml
Form
Liquid
Function
GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
Molecular Weight
71540 MW
Shipping Conditions
Available
Storage Conditions
Store at 2-8°C. Do not freeze.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=M02073-1
Product MSDS
https://www.bosterbio.com/msds?sku=M02073-1
Fragment
Mouse IgG1
Other Gene Names
Glycoprotein Ib platelet subunit alpha
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
Platelet glycoprotein Ib alpha chain
Curated Selection
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