Anti-Hu CD42b Purified GP1BA Monoclonal Antibody

Boster Bio Anti-Hu CD42b Purified GP1BA Monoclonal Antibody (Catalog# M02073-1) . Tested in Flow Cytometry, IHC-F application (s) . This antibody reacts with Primate, Human.

Product Specifications

Background

CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.

Synonyms

BSS, GP1B, VWDP, CD42B, GPIbA, BDPLT1, BDPLT3, DBPLT3

Gene Name

GP1BA

UniProt

P07359

Host

Mouse

Reactivity

Primate, Human

Immunogen

Peripheral blood mononuclear cells of a patient suffering with CLL. The antibody HIP1 reacts with an extracellular epitope of CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa) ; CD42b/c forms a noncovalent complex with CD42a and CD42d.

Clonality

Monoclonal

Clone

Clone: HIP1

Applications

Flow Cytometry, IHC-F

Purification

Purified by protein-A affinity chromatography.

Concentration

1 mg/ml

Dilution

Flow cytometry: 1-4 µg/ml

Form

Liquid

Function

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.