Anti-Hu CD38 Purified Monoclonal Antibody

Boster Bio Anti-Hu CD38 Purified Monoclonal Antibody (Catalog# M00193-1) . Tested in Flow Cytometry, WB, IHC-P, IHC-F application (s) . This antibody reacts with Human.

Product Specifications

Background

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.

Synonyms

ADPRC1, cADPr hydrolase 1, T10, NAD (+) nucleosidase, ADP-ribosyl cyclase 1

Gene Name

CD38

UniProt

P28907

Host

Mouse

Reactivity

Human

Immunogen

Human thymocytes in foetus. The mouse monoclonal antibody HIT2 reacts with an extracellular epitope of CD38, a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes; it is an antigenic marker of lymphoid cells. Its binding is blocked by daratumumab.

Clonality

Monoclonal

Clone

Clone: HIT2

Tissue Specificity

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

Applications

Flow Cytometry, WB, IHC-P, IHC-F

Purification

Purified by protein-A affinity chromatography.

Concentration

1 mg/ml

Form

Liquid

Function

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.