Anti-SIT Purified SIT1 Monoclonal Antibody

SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.

Bacterially produced recombinant intracellular fragment of human SIT. The antibody SIT-01 reacts with an intracellular epitope of SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs.

Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level) . Expressed in T- and B-cell lymphoma.