Anti-PDL1 CD274 Monoclonal Antibody [6H10]

Boster Bio Anti-PDL1 CD274 Monoclonal Antibody [6H10] (Catalog # M00109-3) . Tested in ELISA, WB, IHC-P, ICC, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

PD-L1 plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, PD-L1 modulates the activation threshold of T-cells and limits T-cell effector response (1) . The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (2,3) . Through a yet unknown activating receptor, it may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (4) .

Synonyms

Programmed cell death 1 ligand-1, programmed death ligand 1, PDL1, PDL-1, B7-H1

Gene Name

CD274

UniProt

Q9NZQ7

Host

Mouse

Reactivity

Human, Mouse

Cross Reactivity

PD-L1 Antibody has no cross-reactivity to PD-L2.

Immunogen

Anti-PD-L1 antibody was raised against the extracellular domain of human PD-L1.

Clonality

Monoclonal

Clone

Clone: Clone: 6H10

Tissue Specificity

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Applications

ELISA, WB, IHC-P, ICC, IF

Field of Research

Immunology

Purification

PD-L1 Antibody is supplied as protein A purified IgG1.

Concentration

1 mg/mL

Form

Liquid

Function

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443) . The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410) . Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077) .

Molecular Weight

33275 MW

Shipping Conditions

Available

Storage Conditions

PD-L1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.