Anti-MD-2 LY96 Monoclonal Antibody [1A2E3]

Boster Bio Anti-MD-2 LY96 Monoclonal Antibody [1A2E3] (Catalog # M02107-1) . Tested in ELISA, WB, IHC-P, IF, ICC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) . TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

Synonyms

MD2, MD-2, ly-96, ESOP-1

Gene Name

LY96

UniProt

Q9Y6Y9

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Mouse monoclonal MD-2 antibody was raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2.

Clonality

Monoclonal

Clone

Clone: Clone: 1A2E3

Applications

ELISA, WB, IHC-P, IF, ICC

Field of Research

Innate Immunity

Purification

MD-2 Monoclonal Antibody is Protein A purified.

Concentration

1 mg/mL

Form

Liquid

Function

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869) . Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram- positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030) . Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581) . Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581) .