Anti-beta-Actin ACTB Antibody (biotin)

Boster Bio Anti-beta-Actin ACTB Antibody (biotin) (Catalog # A01263-Biotin) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat, Rabbit, Chicken, Drosophila.

Product Specifications

Background

Actins are highly conserved proteins that are involved in cell motility, structure and integrity, processes that are crucial for tissue development and the development of organism. The actin cytoskeleton is one of the principal drivers of cell motility and is capable of responding to complex signaling cascades. Recent evidence suggests that it may play key roles in regulating apoptosis and aging. Beta actin is one of six different actin isoforms which have been identified. Like GAPDH, beta-Actin is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.

Synonyms

Biotin-Actin, Beta-Actin, Actin

Gene Name

ACTB

UniProt

P60709

Host

Rabbit

Reactivity

Human, Mouse, Rat, Rabbit, Chicken, Drosophila

Cross Reactivity

Biotin-Beta-Actin antibody is human, mouse, rat, rabbit, chicken, and drosophila reactive.

Immunogen

Biotin-Beta-Actin antibody was raised against a synthetic peptide containing 16 amino acids near the amino terminus of beta-actin.

Clonality

Polyclonal

Conjugation

Biotin

Tissue Specificity

Widely expressed, with the highest expression in lung, spleen and thymus.

Applications

ELISA, WB

Field of Research

Homeostasis

Purification

Biotin-Beta-Actin antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253) . Actin exists in both monomeric (G- actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253) . In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947) .