Anti-LAG3 Antibody

Boster Bio Anti-LAG3 Antibody (Catalog # A02869) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2) . It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4) . LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy (5) .

Synonyms

Lymphocyte activating 3, LAG-3, CD223

Gene Name

LAG3

UniProt

P18627

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

At least two antibodies are known to exist; this antibody will only detect the largest isoform.

Immunogen

LAG3 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human LAG3. The immunogen is located within amino acids 110 - 160 of LAG3.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cell Cycle, Cancer, Immunology

Purification

LAG3 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Involved in lymphocyte activation. Binds to HLA class-II antigens.

Molecular Weight

57449 MW

Shipping Conditions

Available

Storage Conditions

LAG3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.