Anti-RNF26 Antibody

RNF26 was identified as a member of a novel C3HC5 ring finger subfamily (1) . RNF26 is ubiquitously expressed in human tissues but has been found to be upregulated in several cancer cell lines including HL-60, HeLa S3, and SW480, as well as 50% of primary gastric cancers. While the substrates of RNF26 ubiquitination have not yet been identified, the upregulation of RNF26 in several types of cancer suggest that it may serve as a target for therapeutic treatment (1) .

E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102) . Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 (PubMed:27368102) . Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102) . Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379) . Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379) .

RNF26 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.