Anti-SLC38A4 Antibody

Boster Bio Anti-SLC38A4 Antibody (Catalog # A07283) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids (1,2) . The transport of cationic amino acids by SLC38A4 is sodium and pH independent, while the transport of neutral amino acids is sodium and pH dependent (2) . Recent evidence suggests that SLC38A4 functions as a regulator of protein synthesis downstream of the hepatocyte nuclear factor 4a during liver development (3) . It has also been suggested that SLC38A4 has ATPase activity and is critically involved in the maintenance of mitochondrial homeostasis and cell survival (4) .

Synonyms

Solute carrier family 38 member 4, sodium-coupled neutral amino acid transporter 4, SNAT4, protein associated with ABC transporters, PAAT, ATA3, NAT3

Gene Name

SLC38A4

UniProt

Q969I6

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

SLC38A4 antibody is human and mouse reactive. SLC38A4 will not cross-react with other members of the SLC38 protein family.

Immunogen

SLC38A4 antibody was raised against an 18 amino acid peptide from near the center of human SLC38A4. The immunogen is located within amino acids 270 - 320 of SLC38A4.

Clonality

Polyclonal

Tissue Specificity

Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels.

Applications

ELISA, WB, IHC-P

Field of Research

Stem Cells, Homeostasis

Purification

SLC38A4 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.