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Anti-SLC36A2 Antibody

Boster Bio Anti-SLC36A2 Antibody (Catalog # A09777) . Tested in ELISA, WB applications. This antibody reacts with Human.

Product Specifications

Background

SLC36A2 is a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline (1,2) . Both SLC36A2 and its paralog SLC36A1 are expressed in neurons, but SLC36A2 localizes to the endoplasmic reticulum and recycling endosome, while SLC36A1 is expressed in the lysosome (2) . SLC36A2 is thought to contribute to neuronal transport and sequestration of amino acids such as glycine, alanine, and proline (2) . Mutations in this gene are associated with iminoglycinuria and hyperglycinuria (3) .

Synonyms

Solute carrier family 36 (proton/amino acid symporter) member 2, proton-coupled amino acid transporter 2, PAT2, TRAMD1

Gene Name

SLC36A2

UniProt

Q495M3

Host

Rabbit

Reactivity

Human

Cross Reactivity

SLC36A2 antibody is human specific. SLC36A2 is predicted to not cross-react with other members of the SLC36 protein family.

Immunogen

SLC36A2 antibody was raised against a 15 amino acid peptide near the amino terminus of human SLC36A2. The immunogen is located within amino acids 30 - 80 of SLC36A2.

Clonality

Polyclonal

Tissue Specificity

Abundantly expressed in kidney and muscle. Expressed in the S1 segment of the proximal tubule close to the glomerulus.

Applications

ELISA, WB

Field of Research

Homeostasis, Neuroscience

Purification

SLC36A2 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity) .

Molecular Weight

53216 MW

Shipping Conditions

Available

Storage Conditions

SLC36A2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A09777

Product MSDS

https://www.bosterbio.com/msds?sku=A09777

Fragment

IgG

Other Gene Names

Solute carrier family 36 (proton/amino acid symporter), member 2

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasm .

Protein Name

Solute carrier family 36 (proton/amino acid symporter), member 2

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