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Anti-VTI1b Antibody

Boster Bio Anti-VTI1b Antibody (Catalog # A07432) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Vesicle transport through interaction with t-SNAREs homolog 1 (VTI1a and VTI1b) are involved in vesicular transport from the late endosomes to the trans-Golgi network (1) . They are both localized in the trans-Golgi network, with VTI1a also found in the Golgi apparatus and VTI1b in endosomes (2,3) . It is thought that VTI1b along with the SNARE protein VAMP8 mediates the fusion of antimicrobial and canonical autophagosomes with lysosomes, an essential process for autophagy (4) .

Synonyms

Vesicle transport through interaction with t-SNAREs 1B, VTI1, VTI1-LIKE, VTI1L, VTI2, v-SNARE, vti1-rp1

Gene Name

VTI1B

UniProt

Q9UEU0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

VTI1b antibody is human, mouse and rat reactive. At least three isoforms of VTI1a are known to exist; this antibody will detect all three isoforms. VTI1b antibody is predicted to not cross-react with VTI1a.

Immunogen

VTI1b antibody was raised against a 17 amino acid peptide near the center of human VTI1b. The immunogen is located within amino acids 150 - 200 of VTI1b.

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues examined.

Applications

ELISA, WB, IHC-P

Field of Research

Autophagy

Purification

VTI1b antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.

Molecular Weight

26688 MW

Shipping Conditions

Available

Storage Conditions

VTI1b antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A07432

Product MSDS

https://www.bosterbio.com/msds?sku=A07432

Fragment

IgG

Other Gene Names

Vesicle transport through interaction with t-SNAREs 1B

Subcellular Location

Early endosome membrane

Prediction Reactivity

Bovine

Protein Name

Vesicle transport through interaction with t-SNAREs 1B

Curated Selection

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