Anti-S1PR2 Antibody

The Sphingosine 1-phosphate receptor 2 (S1PR2) protein was initially identified as G-protein coupled receptor thought to be involved in development (1) and was found to mediate sphingosine 1-phosphate (SPP) -induced cell rounding and neurite retraction (2) . S1PR2 and the related protein S1PR3 (also known as EDG3) are also thought to mediate the SPP-induced cell proliferation, survival, and related signaling events (3) . S1PR2 has also been found to be key regulator in acute vascular inflammation and may be a novel therapeutic target for vascular disorders (4) .

S1PR2 antibody was raised against an 16 amino acid peptide near the carboxy terminus of human S1PR2. The immunogen is located within amino acids 270 - 320 of S1PR2.

Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P) (PubMed:10617617) . S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617) . When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617) . Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251) . Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity) .