Anti-KIR2DS2 Antibody

Boster Bio Anti-KIR2DS2 Antibody (Catalog # A03789) . Tested in ELISA, WB, IF, ICC applications. This antibody reacts with Human.

Product Specifications

Background

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells (1) . The KIR proteins are classified by the number of extracellular immunoglobulin domains and by whether they have a long (L) or short (S) cytoplasmic domain (2,3) . KIR proteins are thought to play an important role in regulation of the immune response (3) . KIR2DS2 downregulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells and is a receptor on natural killer (NK) cells for HLA-C alleles (3,4) .

Synonyms

Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2, KIR2DL3, MHC class I NK cell receptor, Natural killer-associated transcript 5, NKAT5, p58 KIR, p58 natural killer cell receptor clone CL-49, p58 NK receptor

Gene Name

KIR2DS2

UniProt

P43631

Host

Rabbit

Reactivity

Human

Cross Reactivity

KIR2DS2 antibody is human specific. Multiple isoforms are known to exist.

Immunogen

KIR2DS2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KIR2DS2. The immunogen is located within the last 50 amino acids of KIR2DS2.

Clonality

Polyclonal

Applications

ELISA, WB, IF, ICC

Field of Research

Immunology

Purification

KIR2DS2 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

Molecular Weight

33502 MW

Shipping Conditions

Available

Storage Conditions

KIR2DS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Fragment

IgG

Other Gene Names

Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Name

Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2

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