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Anti-PACS2 Antibody

Boster Bio Anti-PACS2 Antibody (Catalog # A08193) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

PACS2 (phosphofurin acidic cluster sorting protein-2), PACS1L, is an 889 amino acid protein that localizes to both the mitochondrion and the lumen of the endoplasmic reticulum (ER) and belongs to the PACS family (1,2) . It is expressed in a broad range of tissues with highest expression in skeletal muscle, brain, heart, testis and pancreas (2, ) . PACS2 interacts with Polycystin-2 and BID and functions as a sorting protein that regulates mitochondria-ER communication and is thought to be involved in ion channel trafficking, specifically direct cluster-containing ion channels to distinct subcellular compartments (3-5) .

Synonyms

Phosphofurin acidic cluster sorting protein 2, PACS-2, PACS1-like protein, PACS1L

Gene Name

PACS2

UniProt

Q86VP3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

PACS2 antibody is human, mouse and rat reactive. At least three isoforms of PACS2 are known to exist; this antibody will detect all three. PACS2 antibody is predicted to not cross-react with PACS1.

Immunogen

PACS2 antibody was raised against a 17 amino acid peptide near the center of human PACS2. The immunogen is located within amino acids 330 - 380 of PACS2.

Clonality

Polyclonal

Tissue Specificity

Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

PACS2 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Multifunctional sorting protein that controls the endoplasmic reticulum (ER) -mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

Molecular Weight

97702 MW

Shipping Conditions

Available

Storage Conditions

PACS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A08193

Product MSDS

https://www.bosterbio.com/msds?sku=A08193

Fragment

IgG

Other Gene Names

Phosphofurin acidic cluster sorting protein 2

Subcellular Location

Endoplasmic reticulum

Protein Name

Phosphofurin acidic cluster sorting protein 2

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