Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-PACS1 Antibody

Boster Bio Anti-PACS1 Antibody (Catalog # A06811-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The phosphofurin acidic cluster sorting protein 1 (PACS1), belongs to the PACS family of cytosolic connector proteins that localize different membrane proteins to the trans-Golgi network (TGN) (1,2) . Mutations in PACS1 cause defects in cranial-neural crest migration during early development, leading to a recognizable intellectual disability syndrome (3) . PACS1, along with the related protein PACS2, also plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance (4) .

Synonyms

Phosphofurin acidic cluster sorting protein 1, PACS-1, MRD17

Gene Name

PACS1

UniProt

Q6VY07

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

PACS1 antibody is human, mouse and rat reactive. Multiple isoforms of PACS1 are known to exist. PACS1 antibody is predicted to not cross-react with PACS2.

Immunogen

PACS1 antibody was raised against a 17 amino acid peptide near the center of human PACS1. The immunogen is located within amino acids 430 - 480 of PACS1.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis, Infectious Diseases, Stem Cells

Purification

PACS1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.

Molecular Weight

104898 MW

Shipping Conditions

Available

Storage Conditions

PACS1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A06811-1

Product MSDS

https://www.bosterbio.com/msds?sku=A06811-1

Fragment

IgG

Other Gene Names

Phosphofurin acidic cluster sorting protein 1

Subcellular Location

Golgi apparatus, trans-Golgi network

Protein Name

Phosphofurin acidic cluster sorting protein 1

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

B4GALNT4 Mouse Monoclonal Antibody [Clone ID: OTI9H2]
CF816145 100 µg

B4GALNT4 Mouse Monoclonal Antibody [Clone ID: OTI9H2]

Ask
View Details
Anti-Dnmt1 Picoband antibody
MBS1750342-01 0.01 mg

Anti-Dnmt1 Picoband antibody

Ask
View Details
Anti-Dnmt1 Picoband antibody
MBS1750342-02 0.1 mg (Carrier Free)

Anti-Dnmt1 Picoband antibody

Ask
View Details
Anti-Dnmt1 Picoband antibody
MBS1750342-03 0.1 mg

Anti-Dnmt1 Picoband antibody

Ask
View Details
Anti-Dnmt1 Picoband antibody
MBS1750342-04 0.1 mg (Cy3)

Anti-Dnmt1 Picoband antibody

Ask
View Details
Anti-Dnmt1 Picoband antibody
MBS1750342-05 0.1 mg (Biotin)

Anti-Dnmt1 Picoband antibody

Ask
View Details