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Anti-C2 domain-containing protein 3 C2CD3 Antibody

Boster Bio Anti-C2 domain-containing protein 3 C2CD3 Antibody (Catalog # A08841) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

C2CD3, a putative calcium-dependent lipid-binding protein, is an essential regulator of intracellular transduction of the Hedgehog signal (1) . It is localized at the basal body of cilia, mediates calcium-dependent vesicular transport and/or recruitment of proteins and regulates cilium biogenesis by promoting the assembly of centriolar distal appendages critical for docking ciliary vesicles and recruiting other essential ciliogenic proteins (2,3) . C2CD3 directly promotes centriole elongation and OFD1 acts as a negative regulator of C2CD3 (4,5) .

Synonyms

C2 calcium-dependent domain containing 3, C2 domain-containing protein 3

Gene Name

C2CD3

UniProt

Q4AC94

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

C2CD3 antibody is human, mouse and rat reactive.

Immunogen

C2CD3 antibody was raised against an 18 amino acid peptide near the center of human C2CD3. The immunogen is located within amino acids 1490 - 1540 of C2CD3.

Clonality

Polyclonal

Applications

ELISA, WB

Field of Research

Homeostasis, Signal Transduction

Purification

C2CD3 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988) . Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972) . Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3.

Molecular Weight

260389 MW

Shipping Conditions

Available

Storage Conditions

C2CD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Fragment

IgG

Other Gene Names

C2 calcium-dependent domain containing 3

Subcellular Location

Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole

Protein Name

C2 calcium-dependent domain containing 3

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