Anti-Teneurin-3 TENM3 Antibody

The teneurin transmembrane protein 3 (TENM3) is a member of a family of four neuronal cell surface proteins homologous to the Drosophila pair-rule gene Ten-m (1,2) . TENM3 is expressed in cartilaginous cells during postnatal growth in mice (3), as well as the adult eye and optic stalk (4) . Homozygous null mutations in TENM3 causes microphthalmia in humans (5) .

TENM3 antibody was raised against a 17 amino acid peptide near the amino terminus of human TENM3. The immunogen is located within the first 50 amino acids of TENM3.

Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus.

Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC) . May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes.