Anti-MALT1 Antibody

Boster Bio Anti-MALT1 Antibody (Catalog # A01599) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

MALT1 was initially identified as a novel gene that was recurrently rearranged in t (11;18) (q21; q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1) . MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2,3) . MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4) .

Synonyms

Mucosa associated lymphoid tissue lymphoma translocation 1, IMD12, MLT, MLT1

Gene Name

MALT1

UniProt

Q9UDY8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

MALT1 antibody is human, mouse and rat reactive. At least two isoforms of MALT1 are known to exist; this antibody will detect both isoforms.

Immunogen

MALT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MALT1. The immunogen is located within amino acids 630 - 680 of MALT1.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cancer, Immunology

Purification

MALT1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity) .