Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Zinc finger protein GLIS2 GLIS2 Antibody

Boster Bio Anti-Zinc finger protein GLIS2 GLIS2 Antibody (Catalog # A07390) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

GLIS2, also known as neuronal Krueppel-like, is a 524 amino acid protein that belongs to the GLI C2H2-type zinc-finger protein family (1) . GLIS2 can act either as a transcription repressor or as a transcription activator and may be involved in neuron differentiation (1,2) . GLIS2 is expressed at high levels in kidney and at low levels in heart, lung and placenta. Mutations of GLIS2 have been suggested to be associated with development of progressive chronic kidney disease with characteristics resembling nephronophthisis (3,4) .

Synonyms

GLIS family zinc finger 2, GLI-similar 2, neuronal krueppel-like protein, NKL, NPHP7

Gene Name

GLIS2

UniProt

Q9BZE0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

GLIS2 antibody is human, mouse and rat reactive.

Immunogen

GLIS2 antibody was raised against an 18 amino acid peptide near the center of human GLIS2. The immunogen is located within amino acids 260 - 310 of GLIS2.

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon.

Applications

ELISA, WB, IHC-P

Field of Research

Stem Cells, Neuroscience

Purification

GLIS2 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity) . Represses the Hedgehog-dependent expression of Wnt4 (By similarity) . Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity) . Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity) . .

Molecular Weight

55689 MW

Shipping Conditions

Available

Storage Conditions

GLIS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A07390

Product MSDS

https://www.bosterbio.com/msds?sku=A07390

Fragment

IgG

Other Gene Names

GLIS family zinc finger 2

Subcellular Location

Nucleus speckle . Cytoplasm .

Protein Name

GLIS family zinc finger 2

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Cow Fibroblast Growth Factor 5 (FGF5) ELISA Kit
abx512826 96 Tests

Cow Fibroblast Growth Factor 5 (FGF5) ELISA Kit

Ask
View Details
Mouse Agrin, Agrn ELISA KIT
ELI-04316m 96 Tests

Mouse Agrin, Agrn ELISA KIT

Ask
View Details
Ccdc181 (NM_001014131) Rat Tagged ORF Clone Lentiviral Particle
RR205104L4V 200 µL

Ccdc181 (NM_001014131) Rat Tagged ORF Clone Lentiviral Particle

Ask
View Details
ST14 Antibody
A35717-100UL 100 µL

ST14 Antibody

Ask
View Details
Rabbit Polyclonal STK32A Antibody
NBP1-56644 100 µL

Rabbit Polyclonal STK32A Antibody

Ask
View Details
DDX43 Peptide
DF12936-BP 1 mg

DDX43 Peptide

Ask
View Details