Anti-SLC1A7 Antibody

Boster Bio Anti-SLC1A7 Antibody (Catalog # A09067) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

The solute carrier family 1 member 7 (SLC1A7) protein was initially identified as a glutamate transporter coupled to a chloride conductance that is expressed primarily in the retina (1) . More recent evidence indicates that is it widely expressed in peripheral tissues, also (2) . Experiments have shown that SLC1A7 functions as a low-affinity/low-capacity glutamate transport, with an anion channel optimized for anion conductance in the negative voltage range (3) . In the retina, SLC1A7 co-localizes with the serum and glucocorticoid dependent kinase SGK1, and its cell surface expression and activity is regulated SGK1 and its isoform SGK3 (4) .

Synonyms

Solute carrier family 1 (glutamate transporter) member 7, AAAT, excitatory amino acid transporter 5, EAAT5

Gene Name

SLC1A7

UniProt

O00341

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

SLC1A7 antibody is human and mouse reactive. Multiple isoforms of SLC1A7 are known to exist.

Immunogen

SLC1A7 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human SLC1A7. The immunogen is located within amino acids 460 - 510 of SLC1A7.

Clonality

Polyclonal

Tissue Specificity

Expressed primarily in retina. Detectable in liver, heart, muscle and brain.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

SLC1A7 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.