Anti-DTX4 Antibody
Boster Bio Anti-DTX4 Antibody (Catalog # A12829) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Product Specifications
Background
The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis (1) . Recent studies have shown that DTX4 is also associated with the innate immune response (2) . Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity (2) .
Synonyms
Deltex 4 E3 ubiquitin ligase, RNF155
Gene Name
DTX4
UniProt
Q9Y2E6
Host
Rabbit
Reactivity
Human
Cross Reactivity
DTX4 antibody is human and mouse reactive. At least two isoforms of DTX4 are known to exist; this antibody will detect both isoforms. DTX4 antibody is predicted to not cross-react with other DTX protein family members.
Immunogen
DTX4 antibody was raised against a 19 amino acid peptide near the center of human DTX4. The immunogen is located within amino acids 230 - 280 of DTX4.
Clonality
Polyclonal
Applications
ELISA, WB, IHC-P, IF
Field of Research
Neuroscience, Innate Immunity
Purification
DTX4 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity) . Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
Molecular Weight
67258 MW
Shipping Conditions
Available
Storage Conditions
DTX4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Fragment
IgG
Other Gene Names
Deltex 4, E3 ubiquitin ligase
Subcellular Location
Cytoplasm .
Protein Name
Deltex 4, E3 ubiquitin ligase
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