Anti-Krueppel-like factor 17 KLF17 Antibody

KLF17, also known as ZNF393, is a member of the Sp/KLF family of transcription factors (1,2) . KLF17 binds to the promoter and negatively regulates the transcription of Id-1, a key metastasis regulator in breast cancer (3) . Suppression of KLF17 promotes breast cancer cell invasion and epithelial-mesenchymal transition (3) . Down-regulated KLF17 expression is also associated tumor invasion and poor prognosis in hepatocellular carcinoma, suggesting that the level of KLF17 expression can serve as a prognostic indicator (4) .

KLF17 antibody is human, mouse and rat reactive. At least two isoforms of KLF17 are known to exist; this antibody will only detect the large isoform. KLF17 antibody is predicted to not cross-react with other KLF proteins.

KLF17 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KLF17. The immunogen is located within the last 50 amino acids of KLF17.

Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity) .