Anti-NOSTRIN Antibody

Boster Bio Anti-NOSTRIN Antibody (Catalog # A06014) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

NOSTRIN. also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins which may function as the modulator of the subcellular localisation and activity of endothelial nitric oxide synthase (eNOS) (1,2) . It decreases NOS3 activity by inducing its translocation away from the plasma membrane (3) . NOSTRIN typically exists as a trimer and is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. NOSTRIN is necessary for proper vascular development in zebrafish and postnatal retinal angiogenesis in mice (4,5) .

Synonyms

Nitric oxide synthase traffic inducer, eNOS-trafficking inducer, Nitric oxide synthase trafficker, BM247 homolog, DaIP2

Gene Name

NOSTRIN

UniProt

Q8IVI9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

NOSTRIN antibody is human, mouse and rat reactive. At least four isoforms are known to exist; this antibody will detect all four isoforms.

Immunogen

NOSTRIN antibody was raised against a 17 amino acid peptide near the carboxy terminus of human NOSTRIN. The immunogen is located within amino acids 430 - 480 of NOSTRIN.

Clonality

Polyclonal

Tissue Specificity

Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over- expressed in placenta from women with pre-eclampsia (at protein level) .

Applications

ELISA, WB, IHC-P, IF

Field of Research

Stem Cells

Purification

NOSTRIN antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.

Molecular Weight

57660 MW

Shipping Conditions

Available

Storage Conditions

NOSTRIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Fragment

IgG

Other Gene Names

Nitric oxide synthase trafficking

Subcellular Location

Isoform 1: Cell membrane

Prediction Reactivity

Bovine

Protein Name

Nitric oxide synthase trafficking

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