Anti-GPRASP1 Antibody

Boster Bio Anti-GPRASP1 Antibody (Catalog # A08358) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

The G protein-coupled receptor associated sorting protein 1 (GPRASP1) is a member of the GPRASP family and is thought to modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors (1,2) . GPRASP1 interacts with receptors such as the D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CNR1) and targets these proteins for degradation in lysosomes (2) . Recently, it has been shown that increased GPRASP1 levels may act as a potential biomarker for breast cancer (3) .

Synonyms

G-protein coupled receptor-associated sorting protein 1, GASP, GASP-1, GASP1

Gene Name

GPRASP1

UniProt

Q5JY77

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

GPRASP1 antibody is human and mouse reactive. This antibody is predicted to not cross-react with GPRASP2.

Immunogen

GPRASP1 antibody was raised against a 15 amino acid peptide near the amino terminus of human GPRASP1. The immunogen is located within amino acids 260 - 310 of GPRASP1.

Clonality

Polyclonal

Tissue Specificity

Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

GPRASP1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Modulates lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.