Anti-RHOG Antibody

Boster Bio Anti-RHOG Antibody (Catalog # A03485) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The ras homolog family member G (RHOG), also known as rho-related GTP-binding protein, is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades (1) . RHOG controls a pathway that requires the microtubule network and activates Rac1 and Cdc42Hs independently of their growth factor signaling pathway (2) . RHOG is also involved in the transcriptional regulation of interferon-gamma and nuclear factor of activated T cells (NFAT) and the regulation of the actin skeleton in lymphocytes (3) .

Synonyms

Ras homolog family member G, Rho-related GTP-binding protein, ARHG

Gene Name

RHOG

UniProt

P84095

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

RHOG antibody is human, mouse and rat reactive.

Immunogen

RHOG antibody was raised against a 15 amino acid peptide near the amino terminus of human RHOG. The immunogen is located within amino acids 40 - 90 of RHOG.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P

Field of Research

Signal Transduction

Purification

RHOG antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.