Anti-Ninjurin-1 NINJ1 Antibody

Boster Bio Anti-Ninjurin-1 NINJ1 Antibody (Catalog # A08377) . Tested in ELISA, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Ninjurin-1 (NINJ1) is a homophilic adhesion molecule that is strongly induced in dorsal root ganglion (DRG) and Schwann cells following nerve injury and promotes neurite outgrowth of DRG neurons (1,2), suggesting that NINJ1 may play a role in nerve regeneration. NINJ1 is transcriptionally regulated by p53 and is induced by DNA damage in a p53-dependent manner. A deficiency of NINJ1 increases p53 expression, suppresses cell proliferation, but enhances apoptosis and premature senescence in a p53-dependent manner as well as radiation-induced cell mortality (3) .

Synonyms

NIN1, NINJURIN, Ninjurin-1, Nerve injury-induced protein 1

Gene Name

NINJ1

UniProt

Q92982

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

NINJ1 antibody is human, mouse and rat reactive.

Immunogen

NINJ1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human NINJ1. The immunogen is located within the last 50 amino acids of NINJ1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin.

Applications

ELISA, IHC-P, IF

Field of Research

Neuroscience, Apoptosis

Purification

NINJ1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.